Mapping Gothicism in HIV/AIDS Art, and the Importance of Art in Understanding Queer Cultural Trauma: Canadian Perspectives

The HIV/AIDS epidemic in Canada continues to be a defining moment in queer trauma and cultural production. Since the 1990s, queer academics and theorists have become increasingly interested in how queer people navigate and negotiate trauma. With the establishment of Queer Studies and Gothic Studies, the two fields have been considered complementary both historically and contemporarily. Queer academics and theorists have discovered that queer cultural production continuously evokes gothic themes, tropes, and atmospheres to understand cultural trauma. Previous research primarily focuses on literature, and my research seeks to expand the field into visual mediums. My research is interested in understanding how queer cultural production’s use of gothic tropes in HIV/AIDS has changed throughout the decades and has shaped queer experience in Canada. I collect Canadian HIV/AIDS visual art, filmography, photography, and mixed-media art to conduct a visual and sociopolitical discourse analysis to understand the phenomenological experience of queer people in Canada. My findings unearth significant change in the ways themes of death, ghosts, and haunting are used in HIV/AIDS art, providing a unique insight into the changing phenomenological experiences of queer people in Canada, which are still heavily haunted by temporal and cultural trauma. My research is significant because it unearths new queer knowledge production, showcasing how queer Canadians have created new forms of understanding cultural trauma that resist and challenge mainstream traumatic discourse

Risk factors for antenatal depression, postnatal depression and parenting stress

<p>Abstract</p> <p>Background</p> <p>Given that the prevalence of antenatal and postnatal depression is high, with estimates around 13%, and the consequences serious, efforts have been made to identify risk factors to assist in prevention, identification and treatment. Most risk factors associated with postnatal depression have been well researched, whereas predictors of antenatal depression have been less researched. Risk factors associated with early parenting stress have not been widely researched, despite the strong link with depression. The aim of this study was to further elucidate which of some previously identified risk factors are most predictive of three outcome measures: antenatal depression, postnatal depression and parenting stress and to examine the relationship between them.</p> <p>Methods</p> <p>Primipara and multiparae women were recruited antenatally from two major hoitals as part of the <it>beyondblue </it>National Postnatal Depression Program <abbrgrp><abbr bid="B1">1</abbr></abbrgrp>. In this subsidiary study, 367 women completed an additional large battery of validated questionnaires to identify risk factors in the antenatal period at 26–32 weeks gestation. A subsample of these women (N = 161) also completed questionnaires at 10–12 weeks postnatally. Depression level was measured by the Beck Depression Inventory (BDI).</p> <p>Results</p> <p>Regression analyses identified significant risk factors for the three outcome measures. (1). Significant predictors for antenatal depression: low self-esteem, antenatal anxiety, low social support, negative cognitive style, major life events, low income and history of abuse. (2). Significant predictors for postnatal depression: antenatal depression and a history of depression while also controlling for concurrent parenting stress, which was a significant variable. Antenatal depression was identified as a mediator between seven of the risk factors and postnatal depression. (3). Postnatal depression was the only significant predictor for parenting stress and also acted as a mediator for other risk factors.</p> <p>Conclusion</p> <p>Risk factor profiles for antenatal depression, postnatal depression and parenting stress differ but are interrelated. Antenatal depression was the strongest predictor of postnatal depression, and in turn postnatal depression was the strongest predictor for parenting stress. These results provide clinical direction suggesting that early identification and treatment of perinatal depression is important.</p

A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression

Background: Postnatal depression (PND) is a major depressive disorder in the year following childbirth, which impacts on women, their infants and their families. A range of interventions has been developed to prevent PND. Objectives: To (1) evaluate the clinical effectiveness, cost-effectiveness, acceptability and safety of antenatal and postnatal interventions for pregnant and postnatal women to prevent PND; (2) apply rigorous methods of systematic reviewing of quantitative and qualitative studies, evidence synthesis and decision-analytic modelling to evaluate the preventive impact on women, their infants and their families; and (3) estimate cost-effectiveness. Data sources: We searched MEDLINE, EMBASE, Science Citation Index and other databases (from inception to July 2013) in December 2012, and we were updated by electronic alerts until July 2013. Review methods: Two reviewers independently screened titles and abstracts with consensus agreement. We undertook quality assessment. All universal, selective and indicated preventive interventions for pregnant women and women in the first 6 postnatal weeks were included. All outcomes were included, focusing on the Edinburgh Postnatal Depression Scale (EPDS), diagnostic instruments and infant outcomes. The quantitative evidence was synthesised using network meta-analyses (NMAs). A mathematical model was constructed to explore the cost-effectiveness of interventions contained within the NMA for EPDS values. Results: From 3072 records identified, 122 papers (86 trials) were included in the quantitative review. From 2152 records, 56 papers (44 studies) were included in the qualitative review. The results were inconclusive. The most beneficial interventions appeared to be midwifery redesigned postnatal care [as shown by the mean 12-month EPDS score difference of –1.43 (95% credible interval –4.00 to 1.36)], person-centred approach (PCA)-based and cognitive–behavioural therapy (CBT)-based intervention (universal), interpersonal psychotherapy (IPT)-based intervention and education on preparing for parenting (selective), promoting parent–infant interaction, peer support, IPT-based intervention and PCA-based and CBT-based intervention (indicated). Women valued seeing the same health worker, the involvement of partners and access to several visits from a midwife or health visitor trained in person-centred or cognitive–behavioural approaches. The most cost-effective interventions were estimated to be midwifery redesigned postnatal care (universal), PCA-based intervention (indicated) and IPT-based intervention in the sensitivity analysis (indicated), although there was considerable uncertainty. Expected value of partial perfect information (EVPPI) for efficacy data was in excess of £150M for each population. Given the EVPPI values, future trials assessing the relative efficacies of promising interventions appears to represent value for money. Limitations: In the NMAs, some trials were omitted because they could not be connected to the main network of evidence or did not provide EPDS scores. This may have introduced reporting or selection bias. No adjustment was made for the lack of quality of some trials. Although we appraised a very large number of studies, much of the evidence was inconclusive. Conclusions: Interventions warrant replication within randomised controlled trials (RCTs). Several interventions appear to be cost-effective relative to usual care, but this is subject to considerable uncertainty. Future work recommendations: Several interventions appear to be cost-effective relative to usual care, but this is subject to considerable uncertainty. Future research conducting RCTs to establish which interventions are most clinically effective and cost-effective should be considered

A high-resolution melt curve toolkit to identify lineage-defining SARS-CoV-2 mutations

The emergence of severe acute respiratory syndrome 2 (SARS-CoV-2) variants of concern (VOCs), with mutations linked to increased transmissibility, vaccine escape and virulence, has necessitated the widespread genomic surveillance of SARS-CoV-2. This has placed a strain on global sequencing capacity, especially in areas lacking the resources for large scale sequencing activities. Here we have developed three separate multiplex high-resolution melting assays to enable the identification of Alpha, Beta, Delta and Omicron VOCs. The assays were evaluated against whole genome sequencing on upper-respiratory swab samples collected during the Alpha, Delta and Omicron [BA.1] waves of the UK pandemic. The sensitivities of the eight individual primer sets were all 100%, and specificity ranged from 94.6 to 100%. The multiplex HRM assays have potential as a tool for high throughput surveillance of SARS-CoV-2 VOCs, particularly in areas with limited genomics facilities

Multicenter Diagnostic Evaluation of OnSite COVID-19 Rapid Test (CTK Biotech) among Symptomatic Individuals in Brazil and the United Kingdom

Evaluating rapid diagnostic tests in diverse populations is essential to improving diagnostic responses as it gives an indication of the accuracy in real-world scenarios. In the case of rapid diagnostic testing within this pandemic, lateral flow tests that meet the minimum requirements for sensitivity and specificity can play a key role in increasing testing capacity, allowing timely clinical management of those infected, and protecting health care systems

Fungal Genomes and Insights into the Evolution of the Kingdom

The kingdom Fungi comprises species that inhabit nearly all ecosystems. Fungi exist as both free-living and symbiotic unicellular and multicellular organisms with diverse morphologies. The genomes of fungi encode genes that enable them to thrive in diverse environments, invade plant and animal cells, and participate in nutrient cycling in terrestrial and aquatic ecosystems. The continuously expanding databases of fungal genome sequences have been generated by individual and large-scale efforts such as Génolevures, Broad Institute's Fungal Genome Initiative, and the 1000 Fungal Genomes Project (http://1000.fungalgenomes.org). These efforts have produced a catalog of fungal genes and genomic organization. The genomic datasets can be utilized to better understand how fungi have adapted to their lifestyles and ecological niches. Large datasets of fungal genomic and transcriptomic data have enabled the use of novel methodologies and improved the study of fungal evolution from a molecular sequence perspective. Combined with microscopes, petri dishes, and woodland forays, genome sequencing supports bioinformatics and comparative genomics approaches as important tools in the study of the biology and evolution of fungi

Gothic Queer Theory: The Haunting (After)effects of HIV/AIDS, Gothicism in Canadian Queer HIV/AIDS Art and Its Importance in Queer Trauma and Resilience

Queer cultural production has strong ties with the Gothic. Using gothic themes, tropes, and atmosphere, queer theorists and artists evoke Gothicism to gain an understanding of their trauma and resilience. The field is small yet emerging, exploring the unique relationship between queerness and the Gothic. Through the lens of gothic queer theory and haunted epistemologies, my paper analyzes two cultural events regarding the HIV/AIDS epidemic and queer experience: (1) how queer Canadians are configured during the epidemic, and (2) how queer artists use Gothicism in HIV/AIDS-related art to respond to trauma. My paper maps out the public response to HIV/AIDS in Canada, rising stigmas, and queer trauma and resilience. Through art and storytelling, queer Canadian artists find new ways of navigating cultural trauma, where art and expression become a place of healing. CW: this work contains themes and mentions of homophobia, trauma, death, and the HIV/AIDS epidemi

Differences in kinetic variables between injured and noninjured novice runners:A prospective cohort study

<p>Objectives: This prospective study examined differences in kinetic variables between injured and noninjured novice female and male runners and their potential contribution to RRIs.</p><p>Design: A prospective cohort study.</p><p>Methods: At baseline vertical ground reaction forces were assessed with an instrumented treadmill equipped with three force measuring transducers. Female participants ran at 8 and 9 km h(-1) and male runners ran at 9 and 10 km h-1. Primary outcome measure was a running related injury (RRI). Participants were novice female and male recreational runners and were followed during a 9-week running program with three running sessions a week.</p><p>Results: One hundred thirty three female and seventy seven male runners participated in this study. Mean age was 37.2 years and the BMI was 23.9 kg m(-2). During the nine week running program 16.2% of the participants sustained an injury and no difference in incidence between female and male runners was seen. In injured male runners loading rate was significantly higher compared to noninjured male runners at both running speeds and contact time in the injured male group was significantly shorter at 9 km h-1. In the group of female injured and noninjured runners no differences on kinetic or spatiotemporal variables were observed. Female runners had significantly higher loading rates compared to male runners but this did not have an effect on the incidence of RRIs.</p><p>Conclusions: This study showed that male injured runners had higher loading rates and shorter contact times than noninjured male runners. In female runners, however, no differences in kinetic or spatiotemporal variables were observed between injured and noninjured novice runners. (C) 2012 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.</p>